Belgorosky A, Chaler E, Rivarola M A
Laboratorio de Investigaciones, Hospital de Pediatría Garrahan, Buenos Aires, Argentina.
Clin Endocrinol (Oxf). 1992 Sep;37(3):203-6. doi: 10.1111/j.1365-2265.1992.tb02311.x.
We determined serum sex hormone-binding globulin (SHBG), serum dehydroepiandrosterone sulphate, serum oestradiol and serum testosterone and its fractions in girls with premature thelarche.
Blood was drawn from girls with recently diagnosed (3-12 weeks) premature thelarche. Serum was kept frozen for at least one year before hormonal determination to exclude precocious puberty by clinical evaluation.
Seventeen girls with premature thelarche aged 0.83-7.16 years were studied, and compared with a group of 22 normal prepubertal girls.
SHBG was measured by saturation analysis and serum dehydroepiandrosterone sulphate, serum total oestradiol and serum total testosterone were determined by radioimmunoassay. Non-SHBG-bound testosterone and free testosterone were calculated from an equation derived from the law of mass action.
Median serum SHBG in premature thelarche was 137 nmol/l (range 64-221), significantly higher than in normal controls, 93.7 (32-172) (P < 0.05) non-parametric test of medians. Serum SHBG decreased significantly with age in controls but not in premature thelarche. No difference was found in serum dehydroepiandrosterone sulphate. Median serum total testosterone (0.34 nmol/l, 0.17-0.97), median serum non-SHBG-bound testosterone (0.04 nmol/l, 0.02-0.10) and median free testosterone (2.2 pmol/l, 1.0-4.5) were significantly lower in premature thelarche than in control (P < 0.001).
Serum SHBG is high and bioavailable T is low in girls with premature thelarche. This might alter the oestrogen/androgen ratio in the breast.
我们测定了乳房过早发育女童的血清性激素结合球蛋白（SHBG）、血清硫酸脱氢表雄酮、血清雌二醇和血清睾酮及其组分。
采集近期诊断（3 - 12周）为乳房过早发育女童的血液。血清在进行激素测定前冷冻保存至少一年，通过临床评估排除性早熟。
研究了17名年龄在0.83 - 7.16岁的乳房过早发育女童，并与22名正常青春前期女童组成的对照组进行比较。
通过饱和分析法测定SHBG，采用放射免疫分析法测定血清硫酸脱氢表雄酮、血清总雌二醇和血清总睾酮。根据质量作用定律推导的公式计算非SHBG结合睾酮和游离睾酮。
乳房过早发育女童的血清SHBG中位数为137 nmol/l（范围64 - 221），显著高于正常对照组的93.7（32 - 172）（中位数的非参数检验，P < 0.05）。对照组中血清SHBG随年龄显著下降，但乳房过早发育女童中未出现此现象。血清硫酸脱氢表雄酮未发现差异。乳房过早发育女童的血清总睾酮中位数（0.34 nmol/l，0.17 - 0.97）、血清非SHBG结合睾酮中位数（0.04 nmol/l，0.02 - 0.10）和游离睾酮中位数（2.2 pmol/l，1.0 - 4.5）显著低于对照组（P < 0.001）。
乳房过早发育女童的血清SHBG较高而生物可利用的睾酮较低。这可能会改变乳房中的雌激素/雄激素比例。
