蛋白质合成抑制：脂肪吸收受损产生的机制
PROTEIN SYNTHESIS INHIBITION: MECHANISM FOR THE PRODUCTION OF IMPAIRED FAT ABSORPTION.
作者信息
SABESIN S M, ISSELBACHER K J
出版信息
Science. 1965 Mar 5;147(3662):1149-51. doi: 10.1126/science.147.3662.1149.
Abstract
Treatment of rats with puromycin and acetoxycycloheximide results in a defect in intestinal lipid transport. Under these conditions rats given corn oil accumulate triglyceride within the intestinal cells and fail to develop the normal postprandial hyperlipemia. The observed interference in lipid transport appears to be a consequence of impaired chylomicron formation.
摘要
用嘌呤霉素和乙酰氧基环己酰亚胺处理大鼠会导致肠道脂质转运出现缺陷。在这些条件下，给予玉米油的大鼠会在肠道细胞内积累甘油三酯，并且无法出现正常的餐后高脂血症。观察到的脂质转运干扰似乎是乳糜微粒形成受损的结果。
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