Holt P R, Dominguez A A
Dig Dis Sci. 1981 Dec;26(12):1109-15. doi: 10.1007/BF01295977.
[3H]Trioleyl glycerol (TO) and [14C]vitamin D3 were perfused intraduodenally for 5 hr in aged (19-21 months) and young adult (4-5 months) Sprague-Dawley rats. The rate of intestinal uptake from the gastrointestinal lumen and transport into the body of these lipids were decreased in the aged animals. Since the distribution of TO lipolytic products in the lumen was unchanged, reduced intestinal uptake rate probably occurred at the mucosal membrane. Furthermore, in the aged rats, the rate of transintestinal transport of both trioleyl glycerol and vitamin D3 was impaired. No evidence for impaired mucosal TO reesterification or for accumulation of vitamin D3 metabolites was found, suggesting that intestinal lipid accumulation resulted from a defect in lipoprotein assembly or in discharge from the mucosal cell. Impaired absorption of lipids may contribute to malnutrition and osteopenia of advancing age.
将[3H]甘油三油酸酯（TO）和[14C]维生素D3经十二指肠灌注到老年（19 - 21个月）和年轻成年（4 - 5个月）的斯普拉格 - 道利大鼠体内5小时。老年动物从胃肠道腔摄取并转运到体内的这些脂质的速率降低。由于TO脂解产物在肠腔内的分布未发生变化，肠道摄取速率降低可能发生在黏膜。此外，在老年大鼠中，甘油三油酸酯和维生素D3的跨肠转运速率均受损。未发现黏膜TO再酯化受损或维生素D3代谢产物积累的证据，这表明肠道脂质积累是由于脂蛋白组装缺陷或从黏膜细胞排出缺陷所致。脂质吸收受损可能导致老年期营养不良和骨质减少。
