Hitoshi S, Sato K, Suzuki K, Sato K, Sakuta M
Department of Neurology, Japanese Red Cross Medical Center.
Rinsho Shinkeigaku. 1992 Jun;32(6):577-82.
We measured serum interleukin-6 (IL-6) levels in 14 patients with Crow-Fukase syndrome. Five out of 14 patients with Crow-Fukase syndrome showed high serum IL-6 levels above 10 pg/ml, which was statistically significant in comparison with control subjects with other neurological diseases. Serial studies of serum IL-6 levels in two patients revealed the increase before the exacerbation of clinical symptoms of edema, and pleural or cardiac effusion, and the fall after the treatment by high dose pulsed methylprednisolone. We suggest that serum IL-6 level appears to be a useful marker to predict its exacerbation. Also we performed immunohistochemical study on cutaneous angioma from three Crow-Fukase syndrome patients using anti-IL-6 antibody. The cytoplasm of endothelial cells of cutaneous angioma from two patients was positively stained, which might imply the abnormality of endothelial cells in Crow-Fukase syndrome.
我们检测了14例克劳-富卡塞综合征患者的血清白细胞介素-6（IL-6）水平。14例克劳-富卡塞综合征患者中有5例血清IL-6水平高于10 pg/ml，与其他神经系统疾病的对照受试者相比，差异具有统计学意义。对2例患者的血清IL-6水平进行的系列研究显示，在水肿、胸腔或心包积液临床症状加重之前血清IL-6水平升高，而在大剂量脉冲甲基强的松龙治疗后下降。我们认为血清IL-6水平似乎是预测其病情加重的有用标志物。此外，我们使用抗IL-6抗体对3例克劳-富卡塞综合征患者的皮肤血管瘤进行了免疫组织化学研究。2例患者皮肤血管瘤内皮细胞的细胞质呈阳性染色，这可能意味着克劳-富卡塞综合征中内皮细胞存在异常。
