在（刘易斯×棕色挪威）F1杂交大鼠中通过注射氯化汞抑制实验性自身免疫性葡萄膜视网膜炎
Inhibition of experimental autoimmune uveoretinitis by mercuric chloride injections in (Lewis x Brown Norway) F1 hybrid rats.
作者信息
Saoudi A, Bellon B, de Kozak Y, Vial M C, Thillaye B, Druet P
机构信息
Pathologie Rénale et Vasculaire, INSERM U28, Hôpital Broussais, Paris, France.
出版信息
Curr Eye Res. 1990;9 Suppl:135-8. doi: 10.3109/02713689008999433.
Experimental autoimmune uveoretinitis (EAU), induced in (LEW X BN) F1 rats by immunization with S antigen (S-Ag) is T cell and antibody (ab) mediated and anti-S-Ag IgE ab have been involved in the occurrence of ocular lesions. (LEW X BN) F1 rats repeatedly injected with HgCl2 develop an autoimmune disease characterized by numerous auto-ab and a high increase of serum IgE level. We hypothesize that large amounts of non anti-S-Ag IgE induced by HgCl2 would compete with anti-S-Ag induced by S-Ag immunization so as to prevent EAU to occur. Indeed (LEW X BN) F1 rats immunized with S-Ag 7 days after the first HgCl2 injection are strongly protected against EAU. The putative role of the different mercury-induced autoimmune phenomena in the protection against EAU are discussed.
通过用S抗原（S-Ag）免疫（LEW X BN）F1大鼠诱导的实验性自身免疫性葡萄膜视网膜炎（EAU）是由T细胞和抗体（ab）介导的，并且抗S-Ag IgE抗体参与了眼部病变的发生。反复注射HgCl2的（LEW X BN）F1大鼠会发展出一种自身免疫性疾病，其特征是大量自身抗体和血清IgE水平的大幅升高。我们假设HgCl2诱导的大量非抗S-Ag IgE会与S-Ag免疫诱导的抗S-Ag竞争，从而预防EAU的发生。事实上，在首次注射HgCl2 7天后用S-Ag免疫的（LEW X BN）F1大鼠对EAU有很强的抵抗力。讨论了不同汞诱导的自身免疫现象在预防EAU中的假定作用。
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