Saoudi A, Bellon B, de Kozak Y, Kuhn J, Vial M C, Thillaye B, Druet P
INSERM U28, Hôpital Broussais, Paris, France.
Immunology. 1991 Oct;74(2):348-54.
Mercuric chloride (HgCl2) induces in Brown-Norway (BN) and (Lewis x Brown-Norway) F1 hybrid rats a transient autoimmune disease characterized by the production of various antibodies to self and non-self antigens and by a dramatic increase of serum IgE. Experimental autoimmune uveoretinitis (EAU) can be induced in Lewis (LEW) and (LEW x BN) F1 hybrid rats by a single immunization with retinal S-antigen (S-Ag). Besides uveoretinitis, animals immunized with S-Ag develop an autoimmune pinealitis (EAP). We demonstrate in this study that (LEW x BN) F1 hybrid rats, injected with HgCl2 7 days before S-Ag immunization, are quite efficiently protected against EAU and EAP. We also show that HgCl2-induced protection is neither due to a cytotoxic effect of HgCl2 nor to CD8+ T-cell dependent mechanisms nor to the HgCl2-induced increase of serum IgE concentration. The role of other hypothetical mechanisms, such as anti-S-Ag anti-idiotypic antibodies and/or HgCl2-induced unbalance between T-helper cell subsets, is discussed.
氯化汞（HgCl2）可在棕色挪威（BN）大鼠以及（刘易斯×棕色挪威）F1杂交大鼠中诱发一种短暂性自身免疫疾病，其特征为产生针对自身和非自身抗原的多种抗体以及血清IgE显著增加。通过单次注射视网膜S抗原（S-Ag），可在刘易斯（LEW）大鼠以及（LEW×BN）F1杂交大鼠中诱发实验性自身免疫性葡萄膜视网膜炎（EAU）。除葡萄膜视网膜炎外，用S-Ag免疫的动物还会发生自身免疫性松果体炎（EAP）。我们在本研究中证明，在S-Ag免疫前7天注射HgCl2的（LEW×BN）F1杂交大鼠可有效预防EAU和EAP。我们还表明，HgCl2诱导的保护作用既不是由于HgCl2的细胞毒性作用，也不是由于CD8 + T细胞依赖性机制，也不是由于HgCl2诱导的血清IgE浓度增加。本文讨论了其他假设机制的作用，例如抗S-Ag抗独特型抗体和/或HgCl2诱导的T辅助细胞亚群失衡。
