人7Sγ球蛋白（G免疫球蛋白）的结构研究。与可结晶（快速）片段相关的一种天然存在蛋白质的进一步观察。
STRUCTURAL STUDIES OF HUMAN 7S GAMMA-GLOBULIN (G IMMUNOGLOBULIN). FURTHER OBSERVATIONS OF A NATURALLY OCCURRING PROTEIN RELATED TO THE CRYSTALLIZABLE (FAST) FRAGMENT.
作者信息
FRANKLIN E C
出版信息
J Exp Med. 1964 Nov 1;120(5):691-709. doi: 10.1084/jem.120.5.691.
Abstract
- Detailed physical, chemical, and immunologic studies of a protein closely related to the Fc fragment and heavy chain of G immunoglobulin (IgG), and elaborated by a subject with a lymphoproliferative disorder are presented. 2. The protein, which has a molecular weight of 51,000, was cleaved into two half molecules by reduction and alkylation. 3. The protein has few if any of the antigenic determinants of the antigen-binding (Fab) papain fragment of IgG, and has a striking similarity in its antigenic properties to the Fc fragment. 4. Fingerprint patterns resemble those of the crystallizable (Fc) fragment, and lack several peptides found in the heavy chain. 5. These findings suggest that the Fc fragment may be a real structural unit of IgG, and raise the possibility of the existence of three different types of polypeptide chains in G immunoglobulin.
摘要
- 本文介绍了对一种与G免疫球蛋白（IgG）的Fc片段和重链密切相关、由一名患有淋巴增殖性疾病的患者产生的蛋白质进行的详细物理、化学和免疫学研究。2. 该蛋白质分子量为51,000，通过还原和烷基化被切割成两个半分子。3. 该蛋白质几乎没有IgG抗原结合（Fab）木瓜蛋白酶片段的抗原决定簇，并且其抗原特性与Fc片段有显著相似性。4. 指纹图谱类似于可结晶（Fc）片段的图谱，并且缺少重链中发现的几种肽。5. 这些发现表明Fc片段可能是IgG的一个真正结构单元，并增加了G免疫球蛋白中存在三种不同类型多肽链的可能性。
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