Millet Y A, Garron J, Devolx B C, Joanny P, Corriol J
C R Seances Soc Biol Fil. 1977;171(2):398-405.
Piridoxilate, at the concentration of 120 mg/kg i.p. in rats, enhanced resistance of these animals to hypoxia (N2 : O2 3,2 %). The electrocorticogram (ECOG) is used to indicate the effectiveness of the drug in lowering the time of electrographic silence, on control (n=19) and pretreated rats (n=12). The ECOG was recorded also during the recovery period under pure oxygen. In pretreated rats, the ECOG records became flat in approximately 551 sec (versus 269 sec on the control group). The latent period of successive steps of cerebral anoxia were delayed in pretreated rats exposed to hypoxia. During the recovery period, piridoxilate seems to enhance the restoration of normal ECOG, as a function of the duration of hypoxia.
吡哆醛以120毫克/千克的腹腔注射浓度给予大鼠时，增强了这些动物对缺氧（氮气：氧气 3,2%）的抵抗力。使用脑电图（ECOG）来表明该药物在缩短脑电图静息时间方面的有效性，实验对象为对照组（n = 19）和预处理大鼠（n = 12）。在纯氧环境下的恢复期也记录了脑电图。在预处理大鼠中，脑电图记录在大约551秒时变得平坦（对照组为269秒）。暴露于缺氧环境的预处理大鼠脑缺氧连续阶段的潜伏期延迟。在恢复期，吡哆醛似乎会根据缺氧持续时间增强脑电图恢复正常的过程。
