Weinstabl C, Mayer N, Spiss C K
Clinic of Anaesthesia and General Intensive Care, University of Vienna, Austria.
Eur J Anaesthesiol. 1992 Nov;9(6):481-4.
Recent investigations revealed that sufentanil increases cerebral blood flow (CBF) and intracranial pressure (ICP) in dogs and man. The aim of our study was to evaluate the impact of sufentanil on cerebral blood flow velocity and ICP in neurosurgical patients. Eight neurosurgical ICU patients with elevated ICP (> 20 mmHg) were examined. Sufentanil was given in incremental doses of 0.5, 1.0 and 2.0 micrograms kg-1. Cerebral blood flow velocity decreased significantly from 54 +/- 4 cm s-1 to 48 +/- 3 cm s-1 with the dose of 1.0 microgram kg-1 sufentanil and 47 +/- 3 cm s-1 with 2.0 micrograms kg-1, respectively (mean +/- SEM). ICP values did not increase with any of the doses studied. Thus, changes of mean arterial pressure which fell with 1.0 microgram kg-1 and 2.0 micrograms kg-1 reflect cerebral perfusion pressure alterations. Although changes of cerebral blood flow velocity revealed changes in vascular tone, ICP remained unaltered.
最近的研究表明，舒芬太尼可增加犬类和人类的脑血流量（CBF）及颅内压（ICP）。我们研究的目的是评估舒芬太尼对神经外科手术患者脑血流速度和ICP的影响。对8名颅内压升高（>20 mmHg）的神经外科重症监护病房患者进行了检查。舒芬太尼以0.5、1.0和2.0微克/千克的递增剂量给药。脑血流速度在给予1.0微克/千克舒芬太尼时从54±4厘米/秒显著降至48±3厘米/秒，给予2.0微克/千克时降至47±3厘米/秒（平均值±标准误）。在所研究的任何剂量下，ICP值均未升高。因此，随着1.0微克/千克和2.0微克/千克剂量下降的平均动脉压变化反映了脑灌注压的改变。尽管脑血流速度的变化显示血管张力发生了变化，但ICP仍保持不变。
