Van Hemelrijck J, Mattheussen M, Wüsten R, Lauwers T, Van Aken H
Department of Anesthesiology, Katholieke Universiteit Leuven, University Hospitals, Belgium.
Acta Anaesthesiol Belg. 1989;40(4):239-45.
The use of sufentanil in neuroanesthesia has been questioned because of a potential increase in intracranial pressure (ICP) in dogs and humans. The effect of sufentanil administration on ICP was studied in 6 dogs with normal and elevated baseline ICP, anesthetized with nitrous oxide and an intravenous piritramide infusion. No significant change in ICP could be demonstrated over a 30 minute observation period after administration of 2 micrograms/kg of sufentanil. The results indicate that this dose of sufentanil does not increase ICP in moderately hyperventilated dogs under stable anesthetic conditions.
由于在犬类和人类中使用舒芬太尼可能会导致颅内压（ICP）升高，其在神经麻醉中的应用受到质疑。在6只基线颅内压正常和升高的犬类中研究了舒芬太尼给药对颅内压的影响，这些犬类使用氧化亚氮和静脉注射匹利卡明进行麻醉。在给予2微克/千克舒芬太尼后30分钟的观察期内，未发现颅内压有显著变化。结果表明，在稳定的麻醉条件下，该剂量的舒芬太尼不会使中度过度通气的犬类颅内压升高。
