Schrander J J, Oudsen S, Forget P P, Kuijten R H
Department of Paediatrics, Academic Hospital Maastricht, University of Maastricht, The Netherlands.
Eur J Pediatr. 1992 Oct;151(10):783-5. doi: 10.1007/BF01959091.
Over a period of 4 years, 88 infants with cow's milk protein intolerance (CMPI) were followed prospectively in order to evaluate the persistence of CMPI and its relationship between either serum IgE levels or RAST results for cow's milk. After exclusion of lactose intolerance, two positive cow's milk elimination challenge tests were considered diagnostic for CMPI. At the age of 1, 2, 3 and 4 years respectively, 85%, 78%, 49% and 33% of the children still were cow's milk intolerant. Initial serum values of IgE greater than or equal to 10 kU/l indicated a late development of tolerance to cow's milk proteins. At the age of 4 years, 90% of infants with initial IgE levels less than 10 kU/l had become tolerant to cow's milk while this was the case for only 47% of infants with initial IgE levels greater than or equal to 10 kU/l. Initial RAST results for cow's milk bore no obvious relationship to outcome.
在4年的时间里，对88名患有牛奶蛋白不耐受（CMPI）的婴儿进行了前瞻性随访，以评估CMPI的持续情况及其与血清IgE水平或牛奶RAST检测结果之间的关系。排除乳糖不耐受后，两次牛奶排除激发试验呈阳性被视为CMPI的诊断标准。分别在1岁、2岁、3岁和4岁时，仍有85%、78%、49%和33%的儿童对牛奶不耐受。初始血清IgE值大于或等于10 kU/l表明对牛奶蛋白的耐受性发展较晚。在4岁时，初始IgE水平低于10 kU/l的婴儿中有90%已对牛奶耐受，而初始IgE水平大于或等于10 kU/l的婴儿中只有47%耐受。初始牛奶RAST检测结果与结局无明显关系。
