Lindberg R E, Arroyave C
J Allergy Clin Immunol. 1986 Oct;78(4 Pt 1):614-8. doi: 10.1016/0091-6749(86)90078-3.
Serum IgE levels of 346 nonallergic and 301 allergic children were measured by an enzyme immunoassay. The data are presented as the geometric mean +/- 95% confidence interval for each age from less than 1 to 12 years of age with those 13 to 16 years of age, pooled. The geometric mean for nonallergic patients increases from 0.9 IU/ml at less than 1 year of age to 45.4 IU/ml at 13 to 16 years of age. By use of an IgE value between confidence intervals of allergic and nonallergic subjects, a cutoff value for each age was established to differentiate allergic from nonallergic children. This value increases from 10 IU/ml at less than 1 year to 100 IU/ml at 13 to 16 years of age. The diagnostic sensitivity and specificity of the assay, based on the cutoff values, average 83% and 91%, respectively.
采用酶免疫分析法检测了346名非过敏儿童和301名过敏儿童的血清IgE水平。数据以1至12岁各年龄段以及13至16岁合并后的几何平均数±95%置信区间呈现。非过敏患者的几何平均数从1岁以下的0.9 IU/ml增加到13至16岁的45.4 IU/ml。通过使用过敏和非过敏受试者置信区间之间的IgE值，为每个年龄确定了一个临界值，以区分过敏儿童和非过敏儿童。该值从1岁以下的10 IU/ml增加到13至16岁的100 IU/ml。基于这些临界值，该检测方法的诊断敏感性和特异性分别平均为83%和91%。
