II型糖尿病患者硬膜外注射利多卡因后的药代动力学改变

Altered pharmacokinetics of lignocaine after epidural injection in type II diabetics.

作者信息

Peeyush M, Ravishankar M, Adithan C, Shashindran C H

机构信息

Department of Anaesthesiology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.

出版信息

Eur J Clin Pharmacol. 1992;43(3):269-71. doi: 10.1007/BF02333021.

DOI:10.1007/BF02333021

PMID:1425890

Abstract

The pharmacokinetics of lignocaine has been compared after epidural anaesthesia in diabetics and non-diabetic patients. Epidural lignocaine 8 mg.kg-1 was given to 8 well controlled Type II diabetic and 8 non-diabetic patients and the plasma drug concentration in serial blood samples were measured by HPLC. The plasma level of lignocaine was lower in diabetics compared to non-diabetics. The peak level was attained at 20 min in both groups. The clearance of the drug was significantly higher, (39.9 vs 16.7 ml.min-1.kg-1) associated with a decreased elimination half-life and mean residence time. The study suggests that the rate of absorption of lignocaine is not altered after epidural administration and that its hepatic metabolism is increased in diabetics compared to non-diabetics.

摘要

已对糖尿病患者和非糖尿病患者硬膜外麻醉后利多卡因的药代动力学进行了比较。向8名病情控制良好的II型糖尿病患者和8名非糖尿病患者给予8mg.kg-1的硬膜外利多卡因，并通过高效液相色谱法测定系列血样中的血浆药物浓度。与非糖尿病患者相比，糖尿病患者的利多卡因血浆水平较低。两组均在20分钟时达到峰值水平。药物清除率显著更高（39.9对16.7ml.min-1.kg-1），伴有消除半衰期和平均驻留时间缩短。该研究表明，硬膜外给药后利多卡因的吸收速率未改变，与非糖尿病患者相比，糖尿病患者其肝脏代谢增加。