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选择性蛋白激酶C抑制剂NPC 15437可导致小鼠记忆保持出现特定缺陷。

The selective protein kinase C inhibitor, NPC 15437, induces specific deficits in memory retention in mice.

作者信息

Mathis C, Lehmann J, Ungerer A

机构信息

Laboratoire de Psychophysiologie, ULP, URA 1295 CNRS, Strasbourg, France.

出版信息

Eur J Pharmacol. 1992 Sep 10;220(1):107-10. doi: 10.1016/0014-2999(92)90020-5.

DOI:10.1016/0014-2999(92)90020-5
PMID:1425976
Abstract

We studied the effects of a selective inhibitor of protein kinase C (PKC), 2,6-diamino-N-[(1-(1-oxotridecyl)-2-piperidinyl]methyl)hexamide (NPC 15437), on acquisition and memory retention of a Y-maze avoidance task in mice. Post-training administration of NPC 15437 (0.1-10 mg/kg i.p.) induced a dose-dependent deficit in retention of the temporal but not the spatial component of the task. This selective amnesia does not reflect state dependence and NPC 15437 (1 mg/kg) had no effect on acquisition and memory retrieval. Our results suggest that this new PKC inhibitor interferes with mechanisms underlying memory consolidation. This is in agreement with recent findings suggesting that PKC is involved in memory processes.

摘要

我们研究了蛋白激酶C（PKC）的选择性抑制剂2,6 - 二氨基 - N - [（1 - （1 - 氧代十三烷基） - 2 - 哌啶基]甲基）己酰胺（NPC 15437）对小鼠Y迷宫回避任务的习得和记忆保持的影响。训练后给予NPC 15437（0.1 - 10毫克/千克，腹腔注射）会导致任务时间成分而非空间成分的保持出现剂量依赖性缺陷。这种选择性失忆并不反映状态依赖性，且NPC 15437（1毫克/千克）对习得和记忆提取没有影响。我们的结果表明，这种新型PKC抑制剂干扰了记忆巩固的潜在机制。这与最近表明PKC参与记忆过程的研究结果一致。

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