大鼠乙醇戒断综合征期间A10多巴胺能神经元放电显著减少。
Marked decrease of A10 dopamine neuronal firing during ethanol withdrawal syndrome in rats.
作者信息
Diana M, Pistis M, Muntoni A, Rossetti Z L, Gessa G
机构信息
B.B. Brodie Department of Neuroscience, University of Cagliari, Italy.
出版信息
Eur J Pharmacol. 1992 Oct 20;221(2-3):403-4. doi: 10.1016/0014-2999(92)90734-l.
The electrophysiological activity of mesoaccumbens dopaminergic neurons was monitored during the ethanol-withdrawal syndrome in ethanol-dependent and in control rats. Spontaneous firing was reduced by about half in ethanol-dependent rats as compared to controls. Likewise, the number of spikes/burst was also reduced in ethanol-dependent rats. These results are consistent with the reduction in dopamine release observed during ethanol-withdrawal syndrome and may provide the basis for the aversive effects of the ethanol-withdrawal syndrome.
在乙醇依赖大鼠和对照大鼠的乙醇戒断综合征期间，监测了伏隔核多巴胺能神经元的电生理活动。与对照组相比，乙醇依赖大鼠的自发放电减少了约一半。同样，乙醇依赖大鼠的峰电位/爆发次数也减少了。这些结果与乙醇戒断综合征期间观察到的多巴胺释放减少一致，并可能为乙醇戒断综合征的厌恶效应提供基础。
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