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Low translational efficiency of the F1-ATPase beta-subunit mRNA largely accounts for the decreased ATPase content in brown adipose tissue mitochondria.

作者信息

Tvrdík P, Kuzela S, Houstĕk J

机构信息

Institute of Physiology, Czechoslovak Academy of Sciences, Prague.

出版信息

FEBS Lett. 1992 Nov 16;313(1):23-6. doi: 10.1016/0014-5793(92)81175-l.

DOI:10.1016/0014-5793(92)81175-l
PMID:1426264
Abstract

The half-life of the F1-ATPase beta-subunit (F1-beta) mRNA in ATPase-poor brown adipose tissue (BAT) (t1/2 = 9.5 h) was found to be 3-7-fold shorter than in liver (t1/2 = 27 h) and heart (t1/2 = 63 h) of mice. When translated in reticulocyte lysate, a 2-3-fold lower efficiency appeared with F1-beta mRNA from BAT than from other tissues. The in vitro synthesized F1-beta protein precursors of BAT, liver and heart origin were imported and processed by mouse liver mitochondria with equal efficiency. The results indicate that the pool of abundant F1-beta mRNA in BAT is not fully translatable, most likely due to its low metabolic stability.

摘要

相似文献

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