Virella G, Yeh C J
Experientia. 1977 Sep 15;33(9):1231-3. doi: 10.1007/BF01922347.
Normal IgG and purified IgG proteins of all 4 subclasses were digested with plasmin. As expected, IgG3 proteins were highly susceptible to degradation. Usually, activation with streptokinase resulted in faster and more accentuated degradation, but normal IgG was more intensely degraded by nonactivated plasmin. The presence of plasmin activators in IgG preparation might account for this observation.
所有4个亚类的正常IgG和纯化IgG蛋白均用纤溶酶消化。正如预期的那样，IgG3蛋白极易被降解。通常，用链激酶激活会导致更快且更明显的降解，但正常IgG被未激活的纤溶酶降解得更剧烈。IgG制剂中纤溶酶激活剂的存在可能解释了这一现象。
