Hedrick P W
Department of Zoology, Arizona State University, Tempe 85287.
Genetics. 1992 Oct;132(2):575-81. doi: 10.1093/genetics/132.2.575.
The cause of the high genetic variability in the major histocompatibility complex (MHC) is not entirely clear. Recently, two reports suggest that female mice prefer to mate with males different from them at the MHC. A model of female choice appropriate for those observations is developed here. Female choice can in fact reduce the observed proportions of homozygotes, maintain genetic polymorphism, influence mating-type frequencies and generate gametic disequilibrium.
主要组织相容性复合体(MHC)中高遗传变异性的原因尚不完全清楚。最近,有两份报告表明,雌性小鼠更喜欢与MHC与自己不同的雄性交配。本文建立了一个适用于这些观察结果的雌性选择模型。事实上,雌性选择可以降低观察到的纯合子比例,维持遗传多态性,影响交配型频率并产生配子不平衡。