Hedrick P W, Thomson G
Division of Biological Sciences, University of Kansas, Lawrence 66045.
Genetics. 1988 May;119(1):205-12. doi: 10.1093/genetics/119.1.205.
There is some empirical evidence that a fetus with an HLA antigen not present in its mother has a higher survival than a fetus sharing antigens with its mother. We have developed both single locus and two-locus theoretical models to examine this mode of selection. First, this immunologically based model appears to have the potential to maintain many alleles at a single locus and to result in an excess of heterozygotes when selection is strong. Second, substantial gametic disequilibrium is maintained between alleles at two loci for this selection mode when recombination is that observed between HLA loci A, B, and DR. Overall, it appears that this mode of selection has the potential to strongly affect genetic variation in the HLA region.
有一些实证证据表明，具有其母亲所没有的HLA抗原的胎儿比与其母亲共享抗原的胎儿具有更高的存活率。我们已经开发了单基因座和双基因座理论模型来研究这种选择模式。首先，这种基于免疫学的模型似乎有可能在单个基因座上维持多个等位基因，并且在选择强烈时导致杂合子过剩。其次，当重组为HLA基因座A、B和DR之间观察到的重组时，这种选择模式在两个基因座的等位基因之间维持着大量的配子不平衡。总体而言，这种选择模式似乎有可能强烈影响HLA区域的遗传变异。
