母胎相互作用与HLA多态性的维持
Maternal-fetal interactions and the maintenance of HLA polymorphism.
作者信息
Hedrick P W, Thomson G
机构信息
Division of Biological Sciences, University of Kansas, Lawrence 66045.
出版信息
Genetics. 1988 May;119(1):205-12. doi: 10.1093/genetics/119.1.205.
Abstract
There is some empirical evidence that a fetus with an HLA antigen not present in its mother has a higher survival than a fetus sharing antigens with its mother. We have developed both single locus and two-locus theoretical models to examine this mode of selection. First, this immunologically based model appears to have the potential to maintain many alleles at a single locus and to result in an excess of heterozygotes when selection is strong. Second, substantial gametic disequilibrium is maintained between alleles at two loci for this selection mode when recombination is that observed between HLA loci A, B, and DR. Overall, it appears that this mode of selection has the potential to strongly affect genetic variation in the HLA region.
摘要
有一些实证证据表明，具有其母亲所没有的HLA抗原的胎儿比与其母亲共享抗原的胎儿具有更高的存活率。我们已经开发了单基因座和双基因座理论模型来研究这种选择模式。首先，这种基于免疫学的模型似乎有可能在单个基因座上维持多个等位基因，并且在选择强烈时导致杂合子过剩。其次，当重组为HLA基因座A、B和DR之间观察到的重组时，这种选择模式在两个基因座的等位基因之间维持着大量的配子不平衡。总体而言，这种选择模式似乎有可能强烈影响HLA区域的遗传变异。
相似文献
1
Maternal-fetal interactions and the maintenance of HLA polymorphism.母胎相互作用与HLA多态性的维持
Genetics. 1988 May;119(1):205-12. doi: 10.1093/genetics/119.1.205.
2
HLA sharing and fertility in Hutterite couples: evidence for prenatal selection against compatible fetuses.哈特派夫妇中的人类白细胞抗原共享与生育能力：针对相容性胎儿进行产前选择的证据。
Am J Reprod Immunol Microbiol. 1988 Dec;18(4):111-5. doi: 10.1111/j.1600-0897.1988.tb00245.x.
3
Immunogenetic determinants of preeclampsia and related pregnancy disorders: a systematic review.子痫前期及相关妊娠疾病的免疫遗传决定因素：一项系统综述。
Obstet Gynecol. 2005 Jul;106(1):162-72. doi: 10.1097/01.AOG.0000167389.97019.37.
4
Polymorphism at the HLA-E locus predates most HLA-A and -B polymorphism.
Hum Immunol. 1992 Mar;33(3):174-84. doi: 10.1016/0198-8859(92)90069-y.
5
Parental HLA compatibility, fetal wastage and neural tube defects: evidence for a T/t-like locus in humans.父母的人类白细胞抗原相容性、胎儿流失与神经管缺陷：人类中存在类似T/t基因座的证据。
Am J Hum Genet. 1984 Sep;36(5):1082-91.
6
Polymorphism of the second component of human complement (C2). Observation of the rare phenotype (C2 2 (= C2 B) and data on the localization of the C2 locus in the HLA region.
Vox Sang. 1979;37(1):47-54. doi: 10.1111/j.1423-0410.1979.tb02268.x.
7
Human leukocyte antigen matching and fetal loss: results of a 10 year prospective study.人类白细胞抗原匹配与胎儿丢失：一项10年前瞻性研究的结果
Hum Reprod. 1998 Jan;13(1):33-8. doi: 10.1093/humrep/13.1.33.
8
Repeated abortions and histocompatibility antigens. Can HLA antigen restricted gene dose effects influence the feto-maternal relationship?
Med Hypotheses. 1979 Aug;5(8):901-8. doi: 10.1016/0306-9877(79)90078-1.
9
HLA-sharing, recurrent spontaneous abortion, and the genetic hypothesis.人类白细胞抗原共享、复发性自然流产与遗传假说
Genetics. 1988 May;119(1):199-204. doi: 10.1093/genetics/119.1.199.
10
Maternal human leukocyte antigen-G polymorphism is not associated with pre-eclampsia in a Chinese Han population.在中国汉族人群中，母体人类白细胞抗原-G多态性与先兆子痫无关。
Tissue Antigens. 2006 Oct;68(4):311-6. doi: 10.1111/j.1399-0039.2006.00667.x.
引用本文的文献
1
Genetic variation in the major histocompatibility complex of the European brown hare (Lepus europaeus) across distinct phylogeographic areas.欧洲野兔（Lepus europaeus）主要组织相容性复合体的遗传变异在不同的系统地理区域。
Immunogenetics. 2014 Jun;66(6):379-92. doi: 10.1007/s00251-014-0772-7. Epub 2014 Apr 18.
2
Coadaptation and conflict, misconception and muddle, in the evolution of genomic imprinting.基因组印记进化中的共适应与冲突、误解与困惑。
Heredity (Edinb). 2014 Aug;113(2):96-103. doi: 10.1038/hdy.2013.97. Epub 2013 Oct 16.
3
Major Histocompatibility Complex (MHC) markers in conservation biology.保护生物学中的主要组织相容性复合体（MHC）标记
Int J Mol Sci. 2011;12(8):5168-86. doi: 10.3390/ijms12085168. Epub 2011 Aug 15.
4
Strong balancing selection at HLA loci: evidence from segregation in South Amerindian families.HLA基因座的强烈平衡选择：来自南美印第安人家族分离的证据。
Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12452-6. doi: 10.1073/pnas.94.23.12452.
5
Limited polymorphism at major histocompatibility complex (MHC) loci in the Swedish moose A. alces.瑞典驼鹿（Alces alces）主要组织相容性复合体（MHC）位点的多态性有限。
Mol Ecol. 1996 Feb;5(1):3-9. doi: 10.1111/j.1365-294x.1996.tb00286.x.
6
HLA-sharing, recurrent spontaneous abortion, and the genetic hypothesis.人类白细胞抗原共享、复发性自然流产与遗传假说
Genetics. 1988 May;119(1):199-204. doi: 10.1093/genetics/119.1.199.
7
Coevolution of the major histocompatibility complex and the t-complex in the mouse. I. Generation and maintenance of high complementarity associations.小鼠主要组织相容性复合体与T复合体的协同进化。I. 高互补性关联的产生与维持。
Genetics. 1989 Jan;121(1):139-51. doi: 10.1093/genetics/121.1.139.
8
The impact of maternal uterine genotype on postnatal growth and adult body size in mice.母体子宫基因型对小鼠出生后生长及成年体型的影响。
Genetics. 1989 May;122(1):193-203. doi: 10.1093/genetics/122.1.193.
9
Heterozygosity at individual amino acid sites: extremely high levels for HLA-A and -B genes.个别氨基酸位点的杂合性：HLA - A和 - B基因的水平极高。
Proc Natl Acad Sci U S A. 1991 Jul 1;88(13):5897-901. doi: 10.1073/pnas.88.13.5897.
10
Influence of MHC and MHC-linked genes on reproduction.主要组织相容性复合体（MHC）及与MHC连锁的基因对生殖的影响。
Am J Hum Genet. 1992 Jan;50(1):1-5.
本文引用的文献
1
Parental HLA compatibility, fetal wastage and neural tube defects: evidence for a T/t-like locus in humans.父母的人类白细胞抗原相容性、胎儿流失与神经管缺陷：人类中存在类似T/t基因座的证据。
Am J Hum Genet. 1984 Sep;36(5):1082-91.
2
Maintenance of histocompatibility polymorphisms.组织相容性多态性的维持
Nature. 1966 Aug 27;211(5052):999-1000. doi: 10.1038/211999a0.
3
Selection in complex genetic systems. I. The symmetric equilibria of the three-locus symmetric viability model.复杂遗传系统中的选择。I. 三位点对称生存力模型的对称平衡
Genetics. 1974 Jan;76(1):135-62. doi: 10.1093/genetics/76.1.135.
4
Antigen sharing in couples in a two-locus ABO-like system.
Ann Hum Genet. 1987 May;51(2):177-80. doi: 10.1111/j.1469-1809.1987.tb01060.x.
5
HLA sharing and spontaneous abortion in humans.人类中的HLA共享与自然流产
Am J Obstet Gynecol. 1985 Apr 15;151(8):1053-8. doi: 10.1016/0002-9378(85)90379-5.
Zotero 插件