Zakharov I A, Nikiforov V S, Stepaniuk E V
Genetika. 1992 Jul;28(7):77-81.
Combinatorial measure of synteny group similarity allowing quantitative comparison of evolutional divergence of genomes with the known distribution of homologous genes along the chromosomes is proposed. Computer simulation of chromosome evolution process resulting in gene localization changes was performed. It is sufficient to fix about 50 large rearrangements, like chromosome breakages, fusions and translocations for disappearance of significant similarity between the daughter and parental genomes, in respect of gene distribution in synteny groups.
提出了一种共线性群相似性的组合度量方法，该方法能够依据同源基因沿染色体的已知分布，对基因组进化差异进行定量比较。对导致基因定位变化的染色体进化过程进行了计算机模拟。就共线性群中的基因分布而言，只需确定约50种大型重排，如染色体断裂、融合和易位，就能使子代基因组和亲代基因组之间的显著相似性消失。
