Deĭneka S E, Prodanchuk N G, Petrunik I O, Davydenko I S, Sinchenko V G, Shelifost A V
Gig Tr Prof Zabol. 1992(4):17-20.
Toxic effects of lead, cadmium, barium, silver, zinc and calcium stearates on the Rh-type cells culture have been revealed. The expressiveness of the cytotoxic action correlated with the toxicity degree for laboratory animals. The strongest (r = 0,98; p less than 0,01) was the correlation between cytotoxicity parameter (the minimal cytoclastic concentration) and the inhalation toxicity parameter in animals (lim(ac)). The results permitted deriving formulae for predicting some toxicity parameters (intraperitoneal LD50, lim(ac)), hygienic regulations (MAC), and showed that the prediction based on cytotoxicity data is more reliable, than that based on toxicometric parameters in short-term experiments used for such purpose.
已揭示硬脂酸铅、镉、钡、银、锌和钙对Rh型细胞培养的毒性作用。细胞毒性作用的表现程度与对实验动物的毒性程度相关。细胞毒性参数（最小细胞破碎浓度）与动物吸入毒性参数（lim(ac)）之间的相关性最强（r = 0.98；p小于0.01）。这些结果使得能够推导预测某些毒性参数（腹腔注射半数致死量、lim(ac)）、卫生规范（职业接触限值）的公式，并且表明基于细胞毒性数据的预测比基于用于此目的的短期实验中的毒理学参数的预测更可靠。
