Di Raimondo F, Murolo D, Milone G, Cacciola E, Giustolisi R
1a Cattedra di Ematologia, Università di Catania, Italy.
Haematologica. 1992 Jul-Aug;77(4):355-6.
A 61-year-old splenectomized male patient affected by hairy cell leukemia (HCL) in relapse was treated with interferon (IFN) at a dosage of 3 x 10(6) U/day. After only 11 days of treatment, IFN was stopped because the patient developed fever, jaundice and respiratory distress. Upon recovery from this infectious episode, the patient was judged to be in complete remission of HCL on the basis of clinical and laboratory findings, and he remained off-therapy for 2 years. When an overt relapse occurred, the patient was again treated with IFN and, after a very short time, he achieved a new, good partial remission that is maintained 28 months later without treatment. This observation remains speculative for understanding the mechanism of action of IFN in other comparable HCL cases.
一名61岁脾切除男性患者，患有复发的毛细胞白血病（HCL），接受剂量为3×10⁶U/天的干扰素（IFN）治疗。治疗仅11天后，因患者出现发热、黄疸和呼吸窘迫而停用IFN。在此次感染性发作恢复后，根据临床和实验室检查结果判断患者的HCL已完全缓解，且停止治疗2年。当明显复发时，患者再次接受IFN治疗，很短时间后，他再次获得良好的部分缓解，且在未治疗的情况下维持了28个月。对于理解IFN在其他类似HCL病例中的作用机制，这一观察结果仍具有推测性。
