门静脉内单独注射转化生长因子-β或联合肝生长因子对犬艾克瘘管肝脏的影响。
Effect on the canine Eck fistula liver of intraportal TGF-beta alone or with hepatic growth factors.
作者信息
Francavilla A, Azzarone A, Carrieri G, Scotti-Foglieni C, Zeng Q H, Cillo U, Porter K, Starzl T E
机构信息
Transplantation Institute, University Health Center of Pittsburgh, Pennsylvania 15213.
出版信息
Hepatology. 1992 Nov;16(5):1267-70.
Transforming growth factor-beta canceled the hepatocyte proliferation caused by transforming growth factor-alpha when the two substances were mixed and administered through a disconnected central portal vein branch after creation of an Eck fistula. In contrast, transforming growth factor-beta had no antidotal action on the stimulatory effects of insulin or full test doses of insulinlike factor-2, hepatocyte growth factor, epidermal growth factor or triiodothymanine. A minor antidotal effect on hepatic stimulatory substance activity could be detected, but only with hepatic stimulatory substance was given in doses smaller than those known to cause maximum stimulatory response. These results suggest a highly specific pharmacological and physiological interaction between transforming growth factor-alpha and transforming growth factor-beta in the modulation of liver growth control.
在建立艾克瘘后，当通过断开的中央门静脉分支混合并给予转化生长因子-α和转化生长因子-β时，转化生长因子-β消除了由转化生长因子-α引起的肝细胞增殖。相比之下，转化生长因子-β对胰岛素、全量试验剂量的胰岛素样因子-2、肝细胞生长因子、表皮生长因子或三碘甲状腺原氨酸的刺激作用没有解毒作用。可以检测到对肝刺激物质活性有轻微的解毒作用，但只有在给予肝刺激物质的剂量小于已知能引起最大刺激反应的剂量时才会出现。这些结果表明，在肝脏生长控制的调节中，转化生长因子-α和转化生长因子-β之间存在高度特异性的药理和生理相互作用。
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