细胞介导免疫反应中的调节机制。V. 小基因座诱导的抑制因子产生的H-2同源性要求。
Regulatory mechanisms in cell-mediated immune responses. V. H-2 homology requirements for the production of a minor locus-induced suppressor factor.
作者信息
Kastner D L, Rich R R, Chu L, Rich S S
出版信息
J Exp Med. 1977 Oct 1;146(4):1152-7. doi: 10.1084/jem.146.4.1152.
Abstract
A mixed leukocyte reaction suppressor factor is produced by spleen cells sensitized in vivo and restimulated in vitro across non-H-2 antigenic barriers. Cells capable of producing this factor appear in the spleens of minor locus-immunized animals later than in animals sensitized to major histocompatibility complex-encoded antigens. However, both H-2 and non H-2-induced factors suppress proliferative responses to any alloantigen. Splenocytes from animals immunized with H-2-identical, minor locus-disparate cells produce suppressor factor in vitro only when restimulated with cells sharing both H-2 and non-H-2 antigens with the in vivo stimulators.
摘要
混合淋巴细胞反应抑制因子由体内致敏并在体外跨越非H-2抗原屏障再次刺激的脾细胞产生。能够产生这种因子的细胞在次要位点免疫动物的脾脏中出现的时间比在对主要组织相容性复合体编码抗原致敏的动物中晚。然而，H-2和非H-2诱导的因子均抑制对任何同种异体抗原的增殖反应。用H-2相同、次要位点不同的细胞免疫的动物的脾细胞，仅在与体内刺激物共享H-2和非H-2抗原的细胞再次刺激时，才在体外产生抑制因子。
相似文献
1
Regulatory mechanisms in cell-mediated immune responses. V. H-2 homology requirements for the production of a minor locus-induced suppressor factor.细胞介导免疫反应中的调节机制。V. 小基因座诱导的抑制因子产生的H-2同源性要求。
J Exp Med. 1977 Oct 1;146(4):1152-7. doi: 10.1084/jem.146.4.1152.
2
Regulatory mechanisms in cell-mediated immune responses. II. A genetically restricted suppressor of mixed lymphocyte reactions released by alloantigen-activated spleen cells.细胞介导免疫反应中的调节机制。II. 同种异体抗原激活的脾细胞释放的混合淋巴细胞反应的基因限制抑制因子。
J Exp Med. 1975 Dec 1;142(6):1391-1402. doi: 10.1084/jem.142.6.1391.
3
Regulatory mechanisms in cell-mediated immune responses. VI. Interaction of H-2 and non-H-2 genes in elaboration of mixed leukocyte reaction suppressor factor.细胞介导免疫反应中的调节机制。VI. H-2基因与非H-2基因在混合白细胞反应抑制因子形成中的相互作用。
J Exp Med. 1977 Nov 1;146(5):1221-33. doi: 10.1084/jem.146.5.1221.
4
Cellular and antigenic requirements for production of mixed leukocyte reaction suppressor factor.混合淋巴细胞反应抑制因子产生的细胞和抗原需求。
J Immunol. 1981 Nov;127(5):2176-82.
5
6
Regulatory mechanisms in cell-mediated immune responses. III. I-region control of suppressor cell interaction with responder cells in mixed lymphocyte reactions.细胞介导免疫反应中的调节机制。III. 混合淋巴细胞反应中I区对抑制细胞与反应细胞相互作用的控制。
J Exp Med. 1976 Mar 1;143(3):672-7. doi: 10.1084/jem.143.3.672.
7
8
Regulatory mechanisms in cell-mediated immune responses. VII. Presence of I-C subregion determinants on mixed leukocyte reaction suppressor factor.细胞介导免疫反应中的调节机制。VII. 混合淋巴细胞反应抑制因子上I-C亚区决定簇的存在。
J Exp Med. 1979 Jan 1;149(1):114-26. doi: 10.1084/jem.149.1.114.
9
Genetic and cellular aspects of xenogeneic mixed leukocyte culture reaction.异种混合白细胞培养反应的遗传和细胞方面
J Exp Med. 1976 Aug 1;144(2):305-18. doi: 10.1084/jem.144.2.305.
10
Effect of recent antigen priming on adoptive immune responses. III. Antigen-induced selective recruitment of subsets of recirculating lymphocytes reactive to H-2 determinants.近期抗原致敏对过继免疫反应的影响。III. 抗原诱导的对H-2决定簇有反应的再循环淋巴细胞亚群的选择性募集。
J Exp Med. 1976 Mar 1;143(3):585-600. doi: 10.1084/jem.143.3.585.
引用本文的文献
1
T lymphocytes responding to Mls-locus antigens are Lyt-1+, 2- and I-A restricted.对 Mls 基因座抗原发生反应的 T 淋巴细胞为 Lyt-1+、2-和 I-A 限制。
Immunogenetics. 1980;10(5):481-97. doi: 10.1007/BF01572583.
2
Generation of primary cytotoxic lymphocytes against non-major histocompatibility complex antigens by anti-Ia serum plus complement-treated lymphocytes.通过抗Ia血清加补体处理的淋巴细胞产生针对非主要组织相容性复合体抗原的原发性细胞毒性淋巴细胞。
J Exp Med. 1980 May 1;151(5):1305-10. doi: 10.1084/jem.151.5.1305.
3
4
Haplotype-specific suppression of cytotoxic T cell induction by antigen inappropriately presented on T cells.抗原在T细胞上不适当呈递时对细胞毒性T细胞诱导的单倍型特异性抑制。
J Exp Med. 1983 Jan 1;157(1):141-54. doi: 10.1084/jem.157.1.141.
本文引用的文献
1
Regulatory mechanisms in cell-mediated immune responses. I. Regulation of mixed lymphocyte reactions by alloantigen-activated thymus-derived lymphocytes.细胞介导免疫反应中的调节机制。I. 同种异体抗原激活的胸腺衍生淋巴细胞对混合淋巴细胞反应的调节。
J Exp Med. 1974 Dec 1;140(6):1588-603. doi: 10.1084/jem.140.6.1588.
2
Immunogenetic and biological aspects of in vitro lymphocyte allotransformation (MLR) in the mouse.小鼠体外淋巴细胞同种异体转化（混合淋巴细胞反应）的免疫遗传学和生物学方面
Transplant Rev. 1973;15:62-88. doi: 10.1111/j.1600-065x.1973.tb00111.x.
3
Regulatory mechanisms in cell-mediated immune responses. IV. Expression of a receptor for mixed lymphocyte reaction suppressor factor on activated T lymphocytes.细胞介导免疫反应中的调节机制。IV. 活化T淋巴细胞上混合淋巴细胞反应抑制因子受体的表达。
J Exp Med. 1976 Nov 2;144(5):1214-26. doi: 10.1084/jem.144.5.1214.
4
Cytotoxic T lymphocytes recognise allogeneic tolerated TNP-conjugated cells.细胞毒性T淋巴细胞识别同种异体耐受的三硝基苯结合细胞。
Nature. 1976 May 13;261(5556):141-2. doi: 10.1038/261141a0.
5
Virus-specific T-cell-mediated cytotoxicity across the H-2 barrier to virus-altered alloantigen.跨越H-2屏障针对病毒改变的同种异体抗原的病毒特异性T细胞介导的细胞毒性。
Nature. 1976 May 13;261(5556):139-41. doi: 10.1038/261139a0.
6
Virus and trinitrophenol hapten-specific T-cell-mediated cytotoxicity against H-2 incompatible target cells.针对H-2不相容靶细胞的病毒和三硝基苯酚半抗原特异性T细胞介导的细胞毒性。
J Exp Med. 1976 Apr 1;143(4):999-1004. doi: 10.1084/jem.143.4.999.
7
In vitro cell-mediated immune responses to the male specific(H-Y) antigen in mice.小鼠对雄性特异性（H-Y）抗原的体外细胞介导免疫反应。
J Exp Med. 1975 Nov 1;142(5):1108-20. doi: 10.1084/jem.142.5.1108.
8
Standardized nomenclature for inbred strains of mice: sixth listing.小鼠近交系标准化命名法：第六版名录
Cancer Res. 1976 Dec;36(12):4333-77.
9
Regulation of cytotoxic lymphocyte responses in vitro by alloantigen-activated spleen cells.同种抗原激活的脾细胞对体外细胞毒性淋巴细胞反应的调节
J Immunol. 1977 Jul;119(1):31-7.
10
T lymphocyte responses to Mls locus antigens involve recognition of H-2 I region gene products.
Nature. 1977 Apr 28;266(5605):840-2. doi: 10.1038/266840a0.
Zotero 插件