细胞介导免疫反应中的调节机制。II. 同种异体抗原激活的脾细胞释放的混合淋巴细胞反应的基因限制抑制因子。
Regulatory mechanisms in cell-mediated immune responses. II. A genetically restricted suppressor of mixed lymphocyte reactions released by alloantigen-activated spleen cells.
作者信息
Rich S S, Rich R R
出版信息
J Exp Med. 1975 Dec 1;142(6):1391-1402. doi: 10.1084/jem.142.6.1391.
Abstract
The mechanism of alloantigen-activated spleen cell suppression of mixed lymphocyte reaction (MLR) is explored in this report. Activated murine suppressor spleen cells elaborated a soluble noncytotoxic factor which suppressed MLR responses by 55-95%. Generation of suppressor factor required both in vivo alloantigen sensitization and specific in vitro restimulation. Suppressor factor was not produced by activated spleen cells which had been treated with anti-Thy-1.2 serum and complement. Antigenic specificity toward alloantigens of the stimulator cells was not demonstrable. In contrast, suppressor factor effectively inhibited MLR response only of responder cells of those strains that shared the D-end and the I-C subregion of the H-2 complex with the cells producing suppressor factor. Therefore, active suppression appears to require an MHC-directed homology relationship between regulating and responder cells in MLR.
摘要
本报告探讨了同种异体抗原激活的脾细胞对混合淋巴细胞反应（MLR）的抑制机制。活化的小鼠抑制性脾细胞产生一种可溶性非细胞毒性因子，该因子可将MLR反应抑制55%-95%。抑制因子的产生既需要体内同种异体抗原致敏，也需要特定的体外再刺激。用抗Thy-1.2血清和补体处理过的活化脾细胞不产生抑制因子。未证明对刺激细胞同种异体抗原具有抗原特异性。相反，抑制因子仅能有效抑制那些与产生抑制因子的细胞共享H-2复合体D端和I-C亚区的品系的反应细胞的MLR反应。因此，在MLR中，主动抑制似乎需要调节细胞和反应细胞之间存在MHC指导的同源关系。
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Cell interactions between histoincompatible T and B lymphocytes. VI. Cooperative responses between lymphocytes derived from mouse donor strains differing at genes in the S and D regions of the H-2 complex.组织相容性不相容的T淋巴细胞与B淋巴细胞之间的细胞相互作用。VI. 源自H-2复合体S区和D区基因不同的小鼠供体品系的淋巴细胞之间的协同反应。
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Activation of T and B lymphocytes in vitro. II. Biological and biochemical properties of an allogeneic effect factor (AEF) active in triggering specific B lymphocytes.体外T和B淋巴细胞的激活。II. 一种在触发特异性B淋巴细胞中起作用的同种异体效应因子（AEF）的生物学和生化特性。
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