QUININE-RESISTANT PLASMODIUM BERGHEI IN MICE.
作者信息
THOMPSON P E, BAYLES A, OLSZEWSKI B, WAITZ J A
出版信息
Science. 1965 May 28;148(3674):1240-1. doi: 10.1126/science.148.3674.1240.
Abstract
During induction of chloroquine resistance, Plasmodium berghei developed resistance to quinine administered in doses near the maximum amounts tolerated by mice. Resistant parasites did not form malarial pigment. Normal sensitivity to both quinine and chloroquine returned and pigment formation resumed during serial passage of the parasites through untreated mice.
摘要
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