Rohrwacher F, Ulrich C, Bernd A, Barth T, Ulrich W D
Augenklinik, Universität Leipzig, Germany.
Int Ophthalmol. 1992 Sep;16(4-5):277-81. doi: 10.1007/BF00917975.
Pr VECP studies in glaucoma patients with the IOP raised artificially by the suction cup method have recently been performed by several authors, who arrived at different results. The reason for those differences may be the changes employed. The refraction changes depend on the shape of the suction cup and the height of the artificial IOP raise. By using contact lenses and a suitably shaped suction cup refraction changes could be compensated for. Studies of the pr VECP with suction cup IOP elevation and simultaneous compensation for refraction changes by applying contact lenses were made on 17 patients with primary open angle glaucoma and 21 healthy volunteers. In healthy subjects pr VECP amplitudes were found unaltered or even slightly increased until 120 mmHg of negative pressure were reached in the cup. Beyond that range they dropped. Latencies remained unaltered over that range of negative pressures. Plotting the pr VECP amplitudes and latencies against ciliary perfusion pressure we obtained unaltered potentials over a range of ca. 20 mmHg, which we interpreted as autoregulative capacity. In the 17 glaucoma patients various degrees of impaired autoregulation were found corresponding to the progression of glaucoma damage.
最近，几位作者对通过吸盘法人为升高眼压的青光眼患者进行了原发性视觉诱发电位（pr VECP）研究，得出了不同的结果。这些差异的原因可能是所采用的变化。屈光变化取决于吸盘的形状和人为升高眼压的高度。通过使用隐形眼镜和形状合适的吸盘，可以补偿屈光变化。对17例原发性开角型青光眼患者和21名健康志愿者进行了pr VECP研究，通过吸盘升高眼压并同时使用隐形眼镜补偿屈光变化。在健康受试者中，在吸盘内负压达到120 mmHg之前，pr VECP振幅未改变甚至略有增加。超过该范围后，振幅下降。在该负压范围内，潜伏期保持不变。将pr VECP振幅和潜伏期与睫状灌注压作图，我们在约20 mmHg的范围内获得了不变的电位，我们将其解释为自动调节能力。在17例青光眼患者中，发现了与青光眼损害进展相对应的不同程度的自动调节功能受损。
