Pillunat L E, Stodtmeister R, Marquardt R, Mattern A
University Eye Clinic, Ulm, FRG.
Int Ophthalmol. 1989 Jan;13(1-2):37-42. doi: 10.1007/BF02028635.
It is widely accepted that a disturbed blood supply of the optic disc may cause (in addition with an increased intraocular pressure) optic nerve fibre damage. Therefore we measured ocular perfusion pressures in 79 healthy subjects. In 18 patients with low tension glaucoma, in 27 patients suffering from ocular hypertension and in 49 glaucoma (OAG) patients. For measuring perfusion pressures we used the technique of oculo-oscillo-dynamography (OODG) as described by Ulrich. Additionally we measured intraocular pressure and systemic blood pressure. In OODG the IOP is simultaneously increased in both eyes by application of a suction cup. After increase of the IOP the negative pressure in the suction cup is slowly and linearly decreased. During this decrease the pulse-depending oscillations of each eye are recorded on a strip-chart-recorder. By means of this method retinal and ciliary perfusion pressures can be separated. As a result we could show that mean arterial blood pressure and systolic retinal perfusion pressure were comparable and not statistically significantly different between the groups examined. The systolic ocular perfusion pressures in patients with low tension glaucoma showed a highly statistically significant reduction compared with the other groups. Between healthy subjects, OAG-patients and patients suffering from ocular hypertension there was no difference in systolic ciliary perfusion pressure detectable.
人们普遍认为，视盘血液供应紊乱（除眼内压升高外）可能导致视神经纤维损伤。因此，我们测量了79名健康受试者的眼灌注压。还测量了18例低眼压性青光眼患者、27例高眼压症患者和49例开角型青光眼（OAG）患者的眼灌注压。为了测量灌注压，我们采用了乌尔里希描述的眼振荡动态血压测量技术（OODG）。此外，我们还测量了眼内压和全身血压。在OODG中，通过应用吸盘同时使双眼眼压升高。眼压升高后，吸盘内的负压缓慢且呈线性下降。在下降过程中，每只眼睛的脉搏依赖性振荡记录在带状图表记录仪上。通过这种方法，可以分离视网膜和睫状灌注压。结果表明，所检查的各组之间平均动脉血压和收缩期视网膜灌注压相当，无统计学显著差异。与其他组相比，低眼压性青光眼患者的收缩期眼灌注压有高度统计学显著降低。在健康受试者、开角型青光眼患者和高眼压症患者之间，未检测到收缩期睫状灌注压有差异。
