Khil M S, Kim J H
Department of Radiation Oncology, Henry Ford Hospital, Detroit, MI 48202.
Henry Ford Hosp Med J. 1992;40(1-2):103-7.
During the last three decades the use of ionizing radiation, both external beam radiotherapy and interstitial radionuclide implant (brachytherapy), has greatly increased for the treatment of cancer of the prostate. The increased use of radiation therapy is in part due to the technological advance of high-energy megavoltage units as well as the steadily improving long-term results of radiotherapy. Because of the comparable tumor control rates, patients with early stage prostate cancer have several therapeutic options for curative treatment including radical prostatectomy, external beam radiation therapy, and interstitial brachytherapy. The role of external beam radiotherapy is discussed in terms of the primary management of early and locally advanced prostate cancers as well as the treatment of residual or recurrent disease after prostatectomy. A new approach combines antimitotic chemotherapeutic agents and radiation therapy for the treatment of locally advanced cancers of the prostate.
在过去三十年中，电离辐射的使用，包括外照射放疗和组织间放射性核素植入（近距离放疗），在前列腺癌治疗中的应用大幅增加。放疗使用增加部分归因于高能兆伏级设备的技术进步以及放疗长期效果的稳步改善。由于肿瘤控制率相当，早期前列腺癌患者有多种根治性治疗选择，包括根治性前列腺切除术、外照射放疗和组织间近距离放疗。本文将讨论外照射放疗在早期和局部晚期前列腺癌的初始治疗以及前列腺切除术后残留或复发性疾病治疗中的作用。一种新方法是将抗有丝分裂化疗药物与放疗联合用于局部晚期前列腺癌的治疗。
