Uhl V, Castro J R, Knopf K, Phillips T L, Collier J M, Petti P L, Daftari I
University of California Lawrence Berkeley Laboratory, University of California Medical Center, San Francisco.
Int J Radiat Oncol Biol Phys. 1992;24(4):755-9. doi: 10.1016/0360-3016(92)90725-w.
Between 1979 and 1989, 17 patients with unfavorable bone sarcoma were treated wholly or in part with heavy charged particle irradiation (helium and/or neon ions) at the University of California Lawrence Berkeley Laboratory. The majority of tumors were located near critical structures such as the spinal cord or brain. Gross tumor was present in all but two patients at the time of irradiation. Six patients were treated for recurrent disease. Histologies included osteosarcoma, Ewing's sarcoma, and recurrent osteoblastoma. Four of the osteosarcomata were believed to have been induced by previous therapeutic irradiation for various tumors. Follow-up time since initiation of radiation ranged from 7 to 118 months (median 40 months). The 5-year Kaplan-Maier local control rate was 48%; the corresponding survival rate was 41%. Over half the patients succumbed to distant metastases despite the majority of patients receiving chemotherapy. In this preliminary study, we have shown that heavy charged particle irradiation can be effectively used for control of bone sarcoma. A Phase II trial is warranted to determine optimal treatment for unresectable or gross residual disease.
1979年至1989年间，加利福尼亚大学劳伦斯伯克利实验室对17例恶性骨肉瘤患者全部或部分采用重带电粒子照射（氦离子和/或氖离子）进行治疗。大多数肿瘤位于脊髓或脑等关键结构附近。照射时，除两名患者外，其余患者均有肉眼可见的肿瘤。6例患者接受复发性疾病治疗。组织学类型包括骨肉瘤、尤因肉瘤和复发性成骨细胞瘤。其中4例骨肉瘤被认为是由先前针对各种肿瘤的治疗性照射诱发的。自开始放疗后的随访时间为7至118个月（中位时间40个月）。采用Kaplan - Maier法计算的5年局部控制率为48%；相应的生存率为41%。尽管大多数患者接受了化疗，但仍有超过半数的患者死于远处转移。在这项初步研究中，我们已表明重带电粒子照射可有效用于控制骨肉瘤。有必要开展II期试验以确定针对不可切除或肉眼残留病灶的最佳治疗方案。
