Castro J R
University of California Lawrence Berkeley Laboratory, CA 94720, USA.
Radiat Environ Biophys. 1995 Mar;34(1):45-8. doi: 10.1007/BF01210545.
The potential of heavy ion therapy for clinical use in cancer therapy stems from the biological parameters of heavy charged particles and their precise dose localization. Biologically, carbon, neon, and other heavy ion beams (up to about silicon) are clinically useful in overcoming the radioresistance of hypoxic tumors, thus increasing the biological effectiveness relative to low linear energy transfer x-ray or electron beams. Cells irradiated by heavy ions show less variation in cell-cycle-related radiosensitivity and decreased repair of radiation injury. The physical parameters of these heavy charged particles allow precise delivery of high doses to tumors while minimizing irradiation of normal tissues. Clinical use requires a close interaction between radiation oncologists, medical physicists, accelerator physicists, engineers, computer scientists, and radiation biologists.
重离子疗法在癌症治疗中临床应用的潜力源于重带电粒子的生物学参数及其精确的剂量定位。从生物学角度来看，碳、氖以及其他重离子束（直至约硅离子束）在临床上有助于克服缺氧肿瘤的放射抗性，从而相对于低线性能量传递的X射线或电子束提高生物学效应。重离子辐照的细胞在细胞周期相关的放射敏感性方面变化较小，且辐射损伤的修复减少。这些重带电粒子的物理参数能够将高剂量精确地传递至肿瘤，同时使正常组织的辐照降至最低。临床应用需要放射肿瘤学家、医学物理学家、加速器物理学家、工程师、计算机科学家和放射生物学家之间密切协作。
