Hutchison J M, Garry F B, Johnson L W, Quackenbush S L, Getzy D M, Jensen W A, Hoover E A
Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523.
J Am Vet Med Assoc. 1992 Oct 1;201(7):1070-6.
Immunodeficiency was diagnosed as the cause of severe debilitating disease characterized by weight loss, failure to grow, and persistent infections that failed to respond to treatment in 12 young llamas. The llamas were affected after maternal-acquired immunity had decreased; failure of passive transfer of immunoglobulins thus was not suspected. Areas of lymph nodes containing T lymphocytes were hypocellular, suggesting T-cell involvement. High serum immunoglobulin concentrations were not found, despite the existence of infectious disease, suggesting at least secondary B-cell involvement. Results of lymphocyte blastogenesis assays were suggestive of B- and T-cell involvement. It was not possible to determine whether the condition was inherited or acquired.
免疫缺陷被诊断为12只幼年美洲驼严重衰弱疾病的病因，这些疾病的特征为体重减轻、生长发育迟缓以及对治疗无反应的持续性感染。这些美洲驼在母源获得性免疫下降后受到影响；因此未怀疑免疫球蛋白被动转移失败。含有T淋巴细胞的淋巴结区域细胞减少，提示T细胞受累。尽管存在传染病，但未发现高血清免疫球蛋白浓度，提示至少有继发性B细胞受累。淋巴细胞增殖试验结果提示B细胞和T细胞均受累。无法确定该病症是遗传性的还是后天获得的。
