Hutchison J M, Garry F B, Belknap E B, Getzy D M, Johnson L W, Ellis R P, Quackenbush S L, Rovnak J, Hoover E A, Cockerell G L
Department of Clinical Sciences, Colorado State University, Fort Collins 80523, USA.
Vet Immunol Immunopathol. 1995 Dec;49(3):209-27. doi: 10.1016/0165-2427(95)05474-x.
The clinicopathologic and immunologic features of 15 llamas affected with juvenile llama immunodeficiency syndrome (JLIDS) are described. Healthy adult (n = 10) and juvenile (n = 10) llamas served as controls. JLIDS llamas were characterized by wasting, and clinically apparent, repeated infections were frequently observed. The median age at which a health problem was first perceived was 11.6 months. All 15 affected llamas died or were killed, and JLIDS was confirmed at necropsy. The median duration of illness was 3.5 months. Lymphocyte blastogenesis assays showed suppressed responses (particularly to Staphylococcus sp. Protein A) in JLIDS llamas. No evidence of retroviral infection was detected. Mild, normocytic, normochromic, non-regenerative anemia, low serum albumin concentration and low to low-normal globulin concentrations were typically found on initial clinical evaluation. Lymph node biopsies showed areas of paracortical depletion. All llamas affected with JLIDS had low serum IgG concentrations, pre-vaccination titers against Clostridium perfringens C and D toxoids of < or = 1:100, and no titer increase following vaccination.
描述了15只患幼年骆驼免疫缺陷综合征（JLIDS）骆驼的临床病理和免疫特征。健康成年骆驼（n = 10）和幼年骆驼（n = 10）作为对照。患JLIDS的骆驼表现为消瘦，且经常观察到明显的反复感染。首次察觉到健康问题的中位年龄为11.6个月。所有15只患病骆驼均死亡或被处死，并在尸检时确诊为JLIDS。疾病的中位持续时间为3.5个月。淋巴细胞增殖试验显示，患JLIDS的骆驼反应受到抑制（尤其是对金黄色葡萄球菌A蛋白）。未检测到逆转录病毒感染的证据。在初始临床评估中，通常发现轻度、正细胞、正色素、非再生性贫血、低血清白蛋白浓度以及低至正常低限的球蛋白浓度。淋巴结活检显示副皮质区有细胞缺失区域。所有患JLIDS的骆驼血清IgG浓度较低，针对产气荚膜梭菌C和D类毒素的接种前效价≤1:100，接种后效价无升高。
