用N-甲基-N-亚硝基脲处理的BALB/c小鼠腺胃腺癌的诱导。
Induction of adenocarcinomas in the glandular stomach of BALB/c mice treated with N-methyl-N-nitrosourea.
作者信息
Tatematsu M, Ogawa K, Hoshiya T, Shichino Y, Kato T, Imaida K, Ito N
机构信息
First Department of Pathology, Nagoya City University Medical School.
出版信息
Jpn J Cancer Res. 1992 Sep;83(9):915-8. doi: 10.1111/j.1349-7006.1992.tb01999.x.
Abstract
Male 6-week-old BALB/c strain animals (groups 1 and 2) received 10 weekly intragastric intubations of 0.5 mg/mouse of N-methyl-N-nitrosourea. At week 11 the forestomachs were resected in group 1 but not group 2. Although many animals in group 2 died due to development of squamous cell carcinomas in the forestomach, development of cancers in the glandular stomach was quite similar in both groups. Well-differentiated adenocarcinomas in groups 1 and 2 were found at low incidence at week 20, rising to 100% at week 40, with two lesions metastasizing to the lymph nodes. Four poorly differentiated adenocarcinomas and 5 signet ring cell carcinomas were also found in 27 glandular stomach tumor-bearing animals.
摘要
6周龄雄性BALB/c品系动物（第1组和第2组）每周接受10次胃内插管，每次剂量为0.5mg/只的N-甲基-N-亚硝基脲。在第11周时，第1组切除了前胃，而第2组未切除。尽管第2组中的许多动物因前胃鳞状细胞癌的发展而死亡，但两组腺胃中的癌症发展情况相当相似。第1组和第2组中高分化腺癌在第20周时发生率较低，在第40周时升至100%，有两个病灶转移至淋巴结。在27只患有腺胃肿瘤的动物中还发现了4例低分化腺癌和5例印戒细胞癌。
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