Tsukamoto Tetsuya, Nakagawa Mitsuru, Kiriyama Yuka, Toyoda Takeshi, Cao Xueyuan
Department of Diagnostic Pathology, Fujita Health University School of Medicine, Toyoake 470-1192, Japan.
Division of Pathology, National Institute of Health Sciences, Tokyo 158-8501, Japan.
Int J Mol Sci. 2017 Aug 3;18(8):1699. doi: 10.3390/ijms18081699.
Although its prevalence is declining, gastric cancer remains a significant public health issue. The bacterium is known to colonize the human stomach and induce chronic atrophic gastritis, intestinal metaplasia, and gastric cancer. Results using a Mongolian gerbil model revealed that infection increased the incidence of carcinogen-induced adenocarcinoma, whereas curative treatment of significantly lowered cancer incidence. Furthermore, some epidemiological studies have shown that eradication of reduces the development of metachronous cancer in humans. However, other reports have warned that human cases of atrophic metaplastic gastritis are already at risk for gastric cancer development, even after eradication of these bacteria. In this article, we discuss the effectiveness of eradication and the morphological changes that occur in gastric dysplasia/cancer lesions. We further assess the control of gastric cancer using various chemopreventive agents.
尽管胃癌的患病率正在下降，但它仍然是一个重大的公共卫生问题。已知这种细菌会在人的胃部定植，并诱发慢性萎缩性胃炎、肠化生和胃癌。使用蒙古沙鼠模型的研究结果显示，这种细菌感染会增加致癌物诱发的腺癌发病率，而对该细菌的根治性治疗则显著降低了癌症发病率。此外，一些流行病学研究表明，根除这种细菌可减少人类异时性癌症的发生。然而，其他报告警告称，即使根除了这些细菌，人类萎缩性化生胃炎病例仍有患胃癌的风险。在本文中，我们讨论了根除这种细菌的有效性以及胃发育异常/癌症病变中发生的形态学变化。我们还进一步评估了使用各种化学预防剂对胃癌的控制情况。
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