Aquilonius S M, Eckernas S A
Neurology. 1977 Sep;27(9):887-9. doi: 10.1212/wnl.27.9.887.
Choline chloride was administered orally (3 to 15 gm per day) to five patients with Huntington chorea. A long-lasting dose-dependent elevation of the concentration of free choline in plasma was obtained and the highest plasma concentrations (25 to 30 mumol per liter) were of the same magnitude as those that increase brain acetylcholine content in the rat. However, the choline treatment did not conclusively alter the involuntary movements of these patients.
对五名患有亨廷顿舞蹈症的患者口服氯化胆碱（每天3至15克）。血浆中游离胆碱浓度出现了持续的剂量依赖性升高，最高血浆浓度（每升25至30微摩尔）与在大鼠中能增加脑乙酰胆碱含量的浓度相当。然而，胆碱治疗并未最终改变这些患者的不自主运动。
