溴隐亭治疗亨廷顿舞蹈症

Bromocriptine in Huntington chorea.

作者信息

Kartzinel R, Hunt R D, Calne D B

出版信息

Arch Neurol. 1976 Jul;33(7):517-8. doi: 10.1001/archneur.1976.00500070059012.

DOI:10.1001/archneur.1976.00500070059012

Abstract

Following a recent report that apomorphine hydrochloride alleviates the involuntary movements of Huntington chorea, we have investigated another dopamine receptor agonist, bromocriptine, in this disease. A double-blind crossover study in six patients showed that rather than improving chorea, bromocriptine induced an exacerbation. This finding supports the view that choreatic movements correlate with overactivity in dopaminergic systems.

摘要

继最近一篇关于盐酸阿扑吗啡可减轻亨廷顿舞蹈症不自主运动的报道之后，我们对另一种多巴胺受体激动剂溴隐亭在该疾病中的作用进行了研究。一项针对6名患者的双盲交叉研究表明，溴隐亭非但没有改善舞蹈症，反而使其加重。这一发现支持了舞蹈样动作与多巴胺能系统活动过度相关的观点。