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转化过程中遗传标记间的不稳定连锁

UNSTABLE LINKAGE BETWEEN GENETIC MARKERS IN TRANSFORMATION.

作者信息

KELLY M S, PRITCHARD R H

出版信息

J Bacteriol. 1965 May;89(5):1314-21. doi: 10.1128/jb.89.5.1314-1321.1965.

DOI:10.1128/jb.89.5.1314-1321.1965
PMID:14293004
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC277646/
Abstract

Kelly, M. (Hammersmith Hospital, London, England), and R. H. Pritchard. Unstable linkage between genetic markers in transformation. J. Bacteriol. 89:1314-1321. 1965.-A new type of association of genetic markers in a transformation system has been discovered. Linkage between certain markers is detectable only under particular conditions of deoxyribonucleic acid (DNA) extraction and is sensitive to dilution of the DNA. The data suggest that this unstable association occurs between markers which are on the same molecule but separated by a molecular distance sufficiently great for linkage to be preserved only by mild DNA extraction procedures and at high concentrations of DNA. Linkage can be stabilized by dilution in the presence of a carrier DNA. By use of these unstable linkages, the genetic map of Bacillus subtilis has been extended in both directions from the aromatic gene cluster.

摘要

凯利，M.（英国伦敦哈默史密斯医院）和R. H. 普里查德。转化中遗传标记的不稳定连锁。《细菌学杂志》89:1314 - 1321。1965年。——在一个转化系统中发现了一种新型的遗传标记关联。某些标记之间的连锁仅在特定的脱氧核糖核酸（DNA）提取条件下才可检测到，并且对DNA的稀释敏感。数据表明，这种不稳定关联发生在位于同一分子上但分子距离足够大的标记之间，以至于只有通过温和的DNA提取程序以及在高浓度DNA条件下才能保持连锁。在载体DNA存在的情况下通过稀释可使连锁稳定。利用这些不稳定连锁，枯草芽孢杆菌的遗传图谱已从芳香族基因簇向两个方向扩展。

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