SINGH A K, SHINTON N K
J Clin Pathol. 1965 May;18(3):349-52. doi: 10.1136/jcp.18.3.349.
Serum pepsinogen levels have been compared in 40 patients with severe megaloblastic anaemia with those obtained from 62 normal subjects, and with levels in 20 patients with pernicious anaemia in remission, 46 patients with iron-deficiency anaemia, and 18 patients with a duodenal ulcer. The range in the normal subjects was 55 to 482 units per ml. It is suggested that a level of below 90 units per ml. should be regarded as indicative of gastric atrophy. It was found to be of value in the early differential diagnosis of severe megaloblastic anaemia. The estimation was found to be reproducible and can be carried out in a routine hospital laboratory.
对40例严重巨幼细胞贫血患者的血清胃蛋白酶原水平与62名正常受试者的水平进行了比较,并与20例处于缓解期的恶性贫血患者、46例缺铁性贫血患者和18例十二指肠溃疡患者的水平进行了比较。正常受试者的范围是每毫升55至482单位。建议将每毫升低于90单位的水平视为胃萎缩的指征。发现其在严重巨幼细胞贫血的早期鉴别诊断中有价值。该测定结果具有可重复性,可在医院常规实验室进行。