Horton M A, Burman J F
Br J Haematol. 1977 May;36(1):23-7. doi: 10.1111/j.1365-2141.1977.tb05751.x.
Serum C3 and C4 levels have been determined in patients with Addisonian pernicious anaemia (PA) and megaloblastic anaemia due to vitamin B12 deficiency from other causes, before and after treatment, in order to study the interaction between vitamin B12 deficiency and complement and the role of complement in the pathogenesis of the gastric lesion of PA. C3 levels are significantly reduced in vitamin B12 deficiency and return to normal on treatment; C3 levels correlate with the degree of anaemia but not with serum vitamin B12 levels at diagnosis. C4 levels are normal. These observations suggest that the observed C3 hypocomplementaemia is not a consequence of immune mechanisms, but may be due to altered synthesis of C3 complement component.
为了研究维生素B12缺乏与补体之间的相互作用以及补体在恶性贫血（PA）胃部病变发病机制中的作用，我们测定了患阿狄森恶性贫血（PA）和因其他原因导致维生素B12缺乏的巨幼细胞贫血患者治疗前后的血清C3和C4水平。维生素B12缺乏时C3水平显著降低，治疗后恢复正常；C3水平与贫血程度相关，但与诊断时的血清维生素B12水平无关。C4水平正常。这些观察结果表明，观察到的C3补体低下并非免疫机制的结果，而可能是由于C3补体成分合成改变所致。
