Metal'nikova N P, Terlets'ka Ia T, Belik Ia V, Chepurko V N
Ukr Biokhim Zh. 1977 Jul-Aug;49(4):103-7.
It is established that the activity of Na+, K+ = ATPase and Mg2+, Ca2+ = ATPase lowers significantly at the paralytic stage of the disease. At earlier stages of the disease preceding the appearance of peculiar neurological symptoms (the seventh and fourteenth days of the incubation period) a decrease of the Mg2+, Ca2+ = ATPase activity was observed in the brain and spinal cord, whereas the Na+, K+ = ATPase activity in the brain remained at the control level up to the appearance of the disease clearly developed symptoms. The Na+, K+ = ATPase activity of the brain on the fourteenth day of the incubation period corresponded to the level of the activity at the paralytic stage of the disease.
已经确定，在疾病的麻痹阶段，Na +，K + -ATP酶和Mg2 +，Ca2 + -ATP酶的活性显著降低。在出现特殊神经症状之前的疾病早期阶段（潜伏期的第7天和第14天），在脑和脊髓中观察到Mg2 +，Ca2 + -ATP酶活性降低，而在疾病明显出现症状之前，脑中的Na +，K + -ATP酶活性保持在对照水平。潜伏期第14天脑的Na +，K + -ATP酶活性与疾病麻痹阶段的活性水平相当。
