Warrington S J, Lewis Y
Charterhouse Clinical Research Limited, London, UK.
Int Clin Psychopharmacol. 1992 Jun;6 Suppl 4:59-64.
The classical tricyclic antidepressant drugs effectively relieve the symptoms of depression, but they have the potential to be severely toxic to the cardiovascular system--including postural hypotension after therapeutic doses and lethal arrhythmias after overdosage. Paroxetine has been shown to be of similar efficacy to the tricyclic antidepressants but has lower cardiovascular toxicity in animal models and has no effects on heart rate, blood pressure or the electrocardiogram in healthy men receiving single 20-40 mg doses. The results of two contrasting studies in depressive patients and healthy men provide strong evidence that therapeutic doses of paroxetine lack any important haemodynamic or electrophysiological effects.
经典的三环类抗抑郁药物能有效缓解抑郁症状，但它们对心血管系统有潜在的严重毒性，包括治疗剂量后的体位性低血压和过量用药后的致死性心律失常。已证明帕罗西汀与三环类抗抑郁药疗效相似，但在动物模型中其心血管毒性较低，且对接受单次20 - 40毫克剂量的健康男性的心率、血压或心电图没有影响。在抑郁症患者和健康男性中进行的两项对比研究结果提供了有力证据，表明治疗剂量的帕罗西汀没有任何重要的血流动力学或电生理效应。
