Cutler N R, Zavadil A P, Linnoila M, Scheinin M, Rudorfer M V, Potter W Z
Biol Psychiatry. 1984 Apr;19(4):549-56.
The effect of chronic administration of desipramine, a relatively specific inhibitor of the reuptake of norepinephrine (NE), on heart rate, blood pressure, and concentrations of NE in plasma was examined in elderly depressed women. Plasma NE concentrations rose significantly following administration of desipramine, while there was no significant change in either heart rate or blood pressure. Implications of these findings are discussed with relationship to the selection of appropriate types and doses of antidepressants in the elderly.
在老年抑郁症女性中，研究了去甲丙咪嗪（一种相对特异性的去甲肾上腺素（NE）再摄取抑制剂）长期给药对心率、血压和血浆中NE浓度的影响。服用去甲丙咪嗪后，血浆NE浓度显著升高，而心率和血压均无显著变化。结合老年人抗抑郁药合适类型和剂量的选择对这些研究结果的意义进行了讨论。
