Ferguson M W
Virchows Arch A Pathol Anat Histol. 1977 Aug 31;375(2):97-113. doi: 10.1007/BF00428098.
Both normal Wistar rat fetuses and those with cleft palate induced by 5-Fluoro-2-Desoxyuridine were studied with a view to elucidating the mechanism of palatal shelf elevation and the pathogenesis of cleft palate. It was postulated that normal shelf elevation is brought about rapidly by an intrinsic turgor shelf force generated by binding of water to mucopolysaccharides. Interference with mucopolysaccharide synthesis would seem to be an important factor in the pathogenesis of some types of cleft palate.
对正常的Wistar大鼠胎儿以及由5-氟-2-脱氧尿苷诱导产生腭裂的胎儿进行了研究，旨在阐明腭突抬高的机制以及腭裂的发病机制。据推测，正常的腭突抬高是由水与粘多糖结合产生的内在膨胀力迅速引起的。干扰粘多糖合成似乎是某些类型腭裂发病机制中的一个重要因素。
