Gulidova G P, Khzardzhian V G, Mikhaĭlova N M
Zh Nevropatol Psikhiatr Im S S Korsakova. 1977;77(8):1179-86.
Lithium (0.5--4 mM) either significantly increase, either completely normalizers the intensity of the oxidative and energy metabolism of the brain mitochondria, decreased by the influence of the blood serum of patients with manic-depressive psychosis and attack like schizophrenia. At the same time lithium gives an insignificant increase in the intensity of processes of phosphorilation in cases of an action of the blood serum of patients with a continuous development of schizophrenia. Processes of phosphorilation become normalized in a joint action on the mitochondria by lithium and antioxidants. In the process of phosphorilation in comparison with the blood serum of patients who do not receive this preparation. It is assumed that an increase in the intensity of the energy metabolism is one of the mechanisms of therapeutical and prophylactic action of lithium.
锂（0.5 - 4毫摩尔）要么显著增加，要么完全使受躁狂抑郁症和精神分裂症样发作患者血清影响而降低的脑线粒体氧化和能量代谢强度恢复正常。同时，在精神分裂症持续发展患者血清作用的情况下，锂使磷酸化过程强度有不显著的增加。锂和抗氧化剂共同作用于线粒体时，磷酸化过程恢复正常。与未服用该制剂患者的血清相比，在磷酸化过程中也是如此。据推测，能量代谢强度的增加是锂治疗和预防作用的机制之一。
