Polianskaia N P, Gulidova G P, Trubnikov V I
Zh Nevropatol Psikhiatr Im S S Korsakova. 1978;78(7):1075-80.
With the aid of a polarographic method it was demonstrated that the blood serum of schizophrenic patients and their relatives, unlike the blood serum taken from normal donors evoke a significant change of the metabolism in the mitochondria of the hemispheric cortex. The intensity of oxidation and respiration control under the influence of these sera change similarly, while the intensity of phosphorylation and oxidation with phosphorylation coupling change significantly to a higher degree under the influence of the blood of probands. Changes in the metabolism indices of mitochondria under the influence of these sera to a significant extent are genetically determined.
借助极谱法已证明，精神分裂症患者及其亲属的血清，与正常献血者的血清不同，会引起大脑半球皮质线粒体代谢的显著变化。在这些血清的影响下，氧化强度和呼吸控制的变化类似，而磷酸化强度以及磷酸化偶联的氧化在先证者血液的影响下变化更为显著。在这些血清的影响下，线粒体代谢指标的变化在很大程度上是由基因决定的。
