Sears E S
Am Fam Physician. 1977 Sep;16(3):145-54.
Human motor behavior is organized around two major neurotransmitter systems in the basal ganglia--dopaminergic and cholinergic. Hypokinetic disease may result from hypofunction of the dopaminergic system or cholinergic hyperfunction. The reverse seems true for many hyperkinetic movement disorders. Drugs which facilitate dopaminergic neurotransmission or which block cholinergic transmission relieve many hypokinetic disorders; the opposite approach is useful in treating many hyperkinetic disorders.
人类运动行为是围绕基底神经节中的两个主要神经递质系统组织起来的——多巴胺能系统和胆碱能系统。运动功能减退疾病可能源于多巴胺能系统功能减退或胆碱能功能亢进。对于许多运动功能亢进性运动障碍来说，情况似乎相反。促进多巴胺能神经传递或阻断胆碱能传递的药物可缓解许多运动功能减退疾病；相反的方法在治疗许多运动功能亢进性疾病中很有用。
