Rondot P, Bathien N
Encephale. 1979;5(1):41-8.
The abnormal movements produced by the psychotropic drugs are related to various physiopathological mechanisms: -- dopaminergic receptors blockage provokes neuroleptic parkinsoniam tremor; -- neuroleptic-induced tardive dyskinesia is similar to 1. Dopa abnormal movements; tardive dyskinesia is due to denervation induced hypersensitivity of the dopamine receptor; the 1. Dopa dyskinesia is probably related to altered responsiveness of these receptors due to an increase in dopaminergic receptor sensitivity; -- antidepressant drugs, particularly lithium, provoke tremor, alleviated by beta blockage; it is probably caused by an abnormal sensitivity of the beta noradrenergic receptors.
——多巴胺能受体阻滞引发抗精神病药所致帕金森震颤;——抗精神病药所致迟发性运动障碍类似于左旋多巴异常运动;迟发性运动障碍是由于去神经支配诱导的多巴胺受体超敏反应所致;左旋多巴运动障碍可能与这些受体因多巴胺能受体敏感性增加而反应性改变有关;——抗抑郁药,尤其是锂盐,引发震颤,β受体阻滞剂可减轻;这可能是由β去甲肾上腺素能受体异常敏感所致。