Suppr超能文献

[精神药物引起的异常运动]

[Abnormal movements induced by psychotropic drugs].

作者信息

Rondot P, Bathien N

出版信息

Encephale. 1979;5(1):41-8.

PMID:477589
Abstract

The abnormal movements produced by the psychotropic drugs are related to various physiopathological mechanisms: -- dopaminergic receptors blockage provokes neuroleptic parkinsoniam tremor; -- neuroleptic-induced tardive dyskinesia is similar to 1. Dopa abnormal movements; tardive dyskinesia is due to denervation induced hypersensitivity of the dopamine receptor; the 1. Dopa dyskinesia is probably related to altered responsiveness of these receptors due to an increase in dopaminergic receptor sensitivity; -- antidepressant drugs, particularly lithium, provoke tremor, alleviated by beta blockage; it is probably caused by an abnormal sensitivity of the beta noradrenergic receptors.

摘要

精神药物产生的异常运动与多种生理病理机制有关

——多巴胺能受体阻滞引发抗精神病药所致帕金森震颤;——抗精神病药所致迟发性运动障碍类似于左旋多巴异常运动;迟发性运动障碍是由于去神经支配诱导的多巴胺受体超敏反应所致;左旋多巴运动障碍可能与这些受体因多巴胺能受体敏感性增加而反应性改变有关;——抗抑郁药,尤其是锂盐,引发震颤,β受体阻滞剂可减轻;这可能是由β去甲肾上腺素能受体异常敏感所致。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验