Keith J C, Moskal T, Eggleston M K, Konczal C, Howerton T L
Department of Biomedical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg 24061-0442.
J Perinatol. 1992 Sep;12(3):210-4.
Changes in maternal and fetal umbilical arterial vasoreactivity during ovine pregnancy-induced hypertension and following intravenous administration of CGS 12970 [3-methyl-2-(3-pyridyl)-1-indoleoctanoic acid] were assessed. Continuous wave Doppler flow velocimetry was used to assess vascular reactivity during normotensive baseline, during ovine pregnancy-induced hypertension triggered by a 72-hour fast, and following thromboxane synthetase inhibition with CGS 12970. Uterine and umbilical arterial systolic/diastolic flow ratios increased significantly with the onset of sustained hypertension. After thromboxane synthetase inhibition, uterine and umbilical artery systolic/diastolic flow ratios were not different from baseline, and maternal blood pressure had returned to baseline values. These data indicate that thromboxane produces maternal and fetal vasoconstriction during ovine pregnancy-induced hypertension. Furthermore, these data provide strong evidence that thromboxane synthetase inhibition allows vasodilation, resulting in improved maternal and fetal condition.
评估了绵羊妊娠高血压期间以及静脉注射CGS 12970（3-甲基-2-（3-吡啶基）-1-吲哚辛酸）后母体和胎儿脐动脉血管反应性的变化。使用连续波多普勒血流速度测定法评估在血压正常的基线期、由72小时禁食引发的绵羊妊娠高血压期间以及用CGS 12970抑制血栓素合成酶之后的血管反应性。随着持续性高血压的出现，子宫和脐动脉收缩压/舒张压血流比值显著增加。在抑制血栓素合成酶后，子宫和脐动脉收缩压/舒张压血流比值与基线无差异，且母体血压已恢复至基线值。这些数据表明，在绵羊妊娠高血压期间，血栓素会导致母体和胎儿血管收缩。此外，这些数据提供了强有力的证据，即抑制血栓素合成酶可实现血管舒张，从而改善母体和胎儿状况。
