Keith J C, Thatcher C D, Schaub R G
Am J Obstet Gynecol. 1987 Jul;157(1):199-203. doi: 10.1016/s0002-9378(87)80380-0.
Pregnancy-induced hypertension was induced in five ewes (gestational day 135; term 150 days) by 72 hours of food deprivation. Maternal arterial pressure, uterine blood flow, platelet function, renal function, and plasma levels of 6-ketoprostaglandin F1 alpha and thromboxane B2 were measured before and during hypertension and after three intravenous injections of U-63,557A; sodium 5-(3'-pyridinylmethyl) benzofuran-2-carboxylate, monohydrate (30 mg/kg every 8 hours). Blood pressure increased (p less than 0.03), and returned to normal after U-63,557A. Left uterine artery blood flow increased after U-63,557A (p less than 0.03). Creatinine clearance decreased during hypertension (p less than 0.03) and increased after U-63,557A. Urine protein increased during hypertension (p less than 0.03) and decreased after treatment. Platelet count dropped during hypertension (p less than 0.03) and was elevated after treatment. Collagen lag phase decreased during hypertension (p less than 0.03) and increased after treatment. After U-63,557A, 6-ketoprostaglandin F1 alpha levels were higher (p less than 0.04) than baseline or hypertensive values. Administration of a thromboxane synthetase inhibitor caused resolution of hemodynamic, renal, and coagulation dysfunctions that occurred in ovine pregnancy-induced hypertension.
通过72小时禁食在五只母羊（妊娠第135天；足月为150天）中诱发妊娠高血压。在高血压发生前、发生期间以及静脉注射三次U-63,557A（5-(3'-吡啶基甲基)苯并呋喃-2-羧酸钠一水合物，每8小时30mg/kg）后，测量母体动脉压、子宫血流量、血小板功能、肾功能以及6-酮前列腺素F1α和血栓素B2的血浆水平。血压升高（p<0.03），U-63,557A注射后恢复正常。U-63,557A注射后左子宫动脉血流量增加（p<0.03）。高血压期间肌酐清除率降低（p<0.03），U-63,557A注射后升高。高血压期间尿蛋白增加（p<0.03），治疗后降低。高血压期间血小板计数下降（p<0.03），治疗后升高。高血压期间胶原延迟期缩短（p<0.03），治疗后延长。U-63,557A注射后，6-酮前列腺素F1α水平高于基线或高血压值（p<0.04）。给予血栓素合成酶抑制剂可使绵羊妊娠高血压中出现的血流动力学、肾脏和凝血功能障碍得到缓解。
